Copper-Catalyzed Coupling of N-Phenoxyacetamides and 2H-Azirines for Synthesis of α-Amino Oxime Ethers

Abstract

Copper-catalyzed coupling reaction involving N-phenoxyacetamides and 2H-azirines is described, in which N–O and C–N bonds are broken and restructured. This protocol provides an efficient strategy for the highly regioselective synthesis of racemic α-amino oxime ethers. In addition, this strategy can be used to modify natural products and is gram-scale compatible.

Key words

copper catalysis - N-phenoxyacetamides - 2H-azirines - ring-opening reactions - α-amino oxime ethers

Publication History

Received: 27 March 2023

Accepted after revision: 19 May 2023

Accepted Manuscript online:
19 May 2023

Article published online:
19 June 2023

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